Improvement of Clinical Symptoms and Gut Microbiome After Fecal Microbiota Transplantation: A Case Study of a 106-Year-Old Man with MODS

Fecal microbiota transplantation (FMT) has been used in a wide variety of diseases. Many researchers hypothesize that the dysbiosis intestinal plays an important role development gut-derived infections; thus, FMT is potential therapeutic target against multiple organ dysfunction syndrome (MODS). A 106-year-old male patient was initially diagnosed with cerebral infarction and pulmonary infection. During course hospitalization, developed MODS. The received single nasogastric infusion sterile-filtered, pathogen-free feces from healthy donor. samples were collected every two days post-infusion to monitor changes composition response treatment. After FMT, MODS severe diarrhea alleviated; patient’s fecal microbiome diversity resembled donor’s microbiome; moreover, his clinical symptoms improved remarkably microbiome. Additionally, no observable side effects noted during These findings warrant further investigation as putative new therapy for treating microbiota-related diseases, such